Climate change have serious impacts on health, including but not limited to dehydration, increased incidence of water and vector-borne diseases, malnutrition related to reduced crop yields, and physical and psychological effects of extreme events. In vulnerable countries where health systems are not able to plan, prepare for or respond to these challenges, the impacts can be particularly devastating. Asian least developed countries (LDCs), namely, Bangladesh, Cambodia, Lao PDR, Myanmar, Nepal, and Timor-Leste, have limited technical capacity of health care systems and personnel to effectively integrate climate-related risks into policy, planning, and regulatory frames, and into interventions to control the burden of climate-sensitive health outcomes. Existing climate early warning systems managed by national meteorological organizations lack systematic coverage of observational data from regions and areas of the countries with high risks of climate-sensitive health outcomes. Climate information services are not adequately tailored to the needs of public health professionals. And primary health care facilities are ill-equipped to prepare for and respond to extreme weather and climate events, lacking information and cost-effective methods and technologies to provide adequate water and sanitation services during extreme events. Recognizing these challenges, the National Adaptation Programmes of Action (NAPAs) of the above-mentioned countries prioritize adaptation to the health risks of climate variability and change. In consultation with stakeholders, this project was designed to increase the adaptive capacity of national health systems and institutions, and sub-level actors, to respond to and manage long-term climate-sensitive health risks, through the following complementary outcomes: •Outcome 1: Institutional capacities are strengthened to effectively integrate climate risks and adaptation options in health sector planning and implementation •Outcome 2: Effective decision-making for health interventions is enabled through generation of information and improved surveillance and/or early warning systems•Outcome 3: Climate resilience is enhanced in health service delivery•Outcome 4.1: Enhanced regional cooperation and knowledge exchange for promoting scale-up and replication of interventions •Outcome 4.2: HNAP are effectively integrated into ongoing NAP processes The regional approach of the project will ensure that catalytic partnerships across countries are developed and the regional-level systematization of lessons and best practices are documented and assessed to develop technical guidelines, manuals and tool-kits, thereby ensuring that these can be replicated and scaled-up across the region.